Adsorption of Components of the Plasma Kinin-Forming System on the Surface of Porphyromonas gingivalis Involves Gingipains as the Major Docking Platforms

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Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.

Enhanced production of proinflammatory bradykinin-related peptides, the kinins, has been suggested to contribute to the pathogenesis of periodontitis, a common inflammatory disease of human gingival tissues. In this report, we describe a plausible mechanism of activation of the kinin-generating system, also known as the contact system or kininogen-kallikrein-kinin system, by the adsorption of i...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 2011

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.00966-10